UvA - DARE ( Digital Academic Repository ) Triple check for antigen specificity of B cells during germinal centre reactions
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منابع مشابه
Triple check for antigen specificity of B cells during germinal centre reactions.
Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differe...
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